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However, celebrex was not statistically different than diclofenac for clinically relevant gi outcomes in the class trial see clinical studies .

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In patients who are known or suspected to be poor CYP2C9 metabolizersi.eCYP2C9*33based on genotype or previous history/experience with other CYP2C9 substratessuch as warfarinphenytoinadminister CELEBREX starting with half the lowest recommended doseAlternative management should be considered in JRA patients identified to be CYP2C9 poor metabolizerssee DOSAGE AND ADMINISTRATION and CLINICAL PHARMACOLOGY

Get emergency medical help if you have signs of an allergic reaction to Celebrexsneezingrunny or stuffy nosewheezing or trouble breathinghivesswelling of your facelipstongueor throat.

Inform patients about the signs and symptoms of serious skin reactionsand to discontinue the use of CELEBREX at the first appearance of skin rash or any other sign of hypersensitivityCELEBREX is contraindicated in patients with previous serious skin reactions to NSAIDssee CONTRAINDICATIONS

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be sure to mention any of the following angiotensin-converting enzyme ace inhibitors such as benazepril lotensin, in lotrel , captopril capoten, in capozide , enalapril vasotec , fosinopril, lisinopril in prinzide, in zestoretic , moexipril univasc, in uniretic , perindopril aceon , quinapril accupril, in accuretic, in quinaretic , ramipril altace , and trandolapril mavik, in tarka ; aspirin and other nonsteroidal anti-inflammatory medications nsaids such as ibuprofen advil, motrin and naproxen aleve, naprosyn , and selective cox-2 inhibitors such as celecoxib celebrex ; diuretics water pills including potassium-sparing diuretics such as amiloride midamor , spironolactone aldactone, in aldactazide , and triamterene dyrenium, in dyazide, in maxzide ; fluconazole diflucan ; lithium lithobid ; phenobarbital; potassium supplements; and rifampin rifadin, rimactane, in rifamate, in rifater .